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Research Interests

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Prion Protein Research


Thomas L. James

Chair, Department of Pharmaceutical Chemsitry
Professor of Chemistry, Pharmaceutical Chemistry, and Radiology


RNA Research

  Overarching goals of our research are (a) to improve the capability for determining dynamic structures of proteins and nucleic acids, i.e., include conformational flexibility in structural descriptions, (b) apply that methodology to the study of small molecule-macromolecule interactions and RNA/protein systems, and (c) use three-dimensional RNA structures and computational search algorithms to discover novel ligands that can serve as lead compounds for drug discovery. Core to this work are multidimensional NMR experiments and calculations. To learn more about our research goals click on a topic at the left.  

Ligand Research